The primary outcomes of the Rhea study are pregnancy outcomes, offspring obesity and cardiovascular risk factors, asthma and atopy, and cognition and behavioral development.
Between 2007 and 2015, we have gathered detailed assessments of health and health behaviors, medical care and quality of life of children and their mothers. Anthropometric measurements, anogenital distance measurements, assessment of body composition and physical activity, spirometry and blood pressure measurement were performed. Moreover within the cohort we have created internal gender and age–adjusted growth curves, which allows estimation of individual growth patterns.
Maternal mental health (anxiety, depressive symptoms, and personality characteristics) during and after pregnancy along with child neurodevelopment have been assessed by clinical psychologists.
We are one of the few studies that have measured micronuclei (MN) frequencies - biomarkers of early genetic effects that have been used to investigate the association between environmental exposures and cancer - in blood samples collected at pregnancy, birth and at 4 years of age.